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Forschungsdatenbank PMU-SQQUID

West Nile and Usutu Virus Infections and Challenges to Blood Safety in the European Union.
Domanović, D; Gossner, CM; Lieshout-Krikke, R; Mayr, W; Baroti-Toth, K; Dobrota, AM; Escoval, MA; Henseler, O; Jungbauer, C; Liumbruno, G; Oyonarte, S; Politis, C; Sandid, I; Vidović, MS; Young, JJ; Ushiro-Lumb, I; Nowotny, N;
Emerg Infect Dis. 2019; 25(6):-1057
Originalarbeiten (Zeitschrift)


Jungbauer Christof


West Nile virus (WNV) and Usutu virus (USUV) circulate in several European Union (EU) countries. The risk of transfusion-transmitted West Nile virus (TT-WNV) has been recognized, and preventive blood safety measures have been implemented. We summarized the applied interventions in the EU countries and assessed the safety of the blood supply by compiling data on WNV positivity among blood donors and on reported TT-WNV cases. The paucity of reported TT-WNV infections and the screening results suggest that blood safety interventions are effective. However, limited circulation of WNV in the EU and presumed underrecognition or underreporting of TT-WNV cases contribute to the present situation. Because of cross-reactivity between genetically related flaviviruses in the automated nucleic acid test systems, USUV-positive blood donations are found during routine WNV screening. The clinical relevance of USUV infection in humans and the risk of USUV to blood safety are unknown.

Useful keywords (using NLM MeSH Indexing)

Blood Donors*

Blood Safety*

Blood Transfusion

Communicable Diseases, Emerging/epidemiology


European Union*


Flavivirus Infections/epidemiology*

Flavivirus Infections/prevention*


Flavivirus Infections/transmission

Flavivirus Infections/virology



Public Health Surveillance

West Nile Fever/epidemiology*

West Nile Fever/prevention*


West Nile Fever/transmission

West Nile Fever/virology

West Nile virus*