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Forschungsdatenbank PMU-SQQUID

The angiotensin-converting enzyme insertion/deletion polymorphism and serum levels of angiotensin-converting enzyme in venous thromboembolism. Data from a case control study.
Ay, C; Bencur, P; Vormittag, R; Sailer, T; Jungbauer, C; Vukovich, T; Mannhalter, C; Pabinger, I;
Thromb Haemost. 2007; 98(4):777-782
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Jungbauer Christof

Abstract

The angiotensin-converting enzyme (ACE) has been suggested to affect blood coagulation and fibrinolysis. Results from literature on the role of the frequent insertion/deletion (I/D) polymorphism in the ACE gene in venous thromboembolism (VTE) are controversial. Only limited data on ACE serum levels inVTE exist. We determined the ACE I/D polymorphism by genotyping and ACE serum levels by an enzymatic assay in 100 high-risk patients with objectively confirmed recurrentVTE and at least one event of an unprovoked deep venous thrombosis or pulmonary embolism. One hundred twenty-five age- and sex-matched healthy individuals served as controls. ACE genotype frequencies were not significantly different between patients (DD: 26.0%, ID: 52.0%, II: 22.0%) and controls (DD: 29.6%, ID: 44.8%, II: 25.6%; p = 0.56). Neither individuals with ACE DD genotype nor those with ACE ID genotype had a higher risk for VTE in comparison to those with ACE II genotype (odds ratio and [95% confidence interval]: 1.0 [0.5-2.1] and 1.4 [0.7-2.6], respectively). Serum ACE levels (U/l) did not differ between patients (median = 25.25, 25th -75th percentile: 20.20-33.70) and controls (24.20, 17.85-34.50, p = 0.49). In the total population involved in the study the ACE DD genotype (n = 63: 36.00 [26.40-43.00]) was associated with higher ACE levels than the ACE ID genotype (n = 108: 24.10 [19.80-31.48], p < 0.001) and the ACE II genotype (n = 54: 19.35 [15.00-22.95], p < 0.001). In conclusion, we found a significant association of the ACE I/D polymorphism with ACE serum levels. However, neither the serum levels nor the I/D genotype were associated with VTE.


Useful keywords (using NLM MeSH Indexing)

ABO Blood-Group System

Adult

Aged

Case-Control Studies

Female

Gene Deletion*

Genotype

Humans

Male

Middle Aged

Peptidyl-Dipeptidase A/genetics*

Polymorphism, Genetic*

Pulmonary Embolism/genetics

Venous Thromboembolism/genetics*

Venous Thrombosis/genetics


Find related publications in this database (Keywords)

angiotensin-converting enzyme
insertion/deletion polymorphism
deep venous thrombosis
pulmonary embolism
venous thromboembolism