Forschungsdatenbank PMU-SQQUID

Genetic diversity of KELnull and KELel: a nationwide Austrian survey.
Körmöczi, GF; Wagner, T; Jungbauer, C; Vadon, M; Ahrens, N; Moll, W; Mühlbacher, A; Ozgül-Gülce, S; Kleinrath, T; Kilga-Nogler, S; Schönitzer, D; Gassner, C;
Transfusion. 2007; 47(4):703-714
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed Full Text

PMU-Autor/inn/en

Jungbauer Christof

Abstract

Besides ABO and RH, the KEL blood group system, including the two antithetical antigens KEL1 and KEL2, is the most important owing to the frequent appearance of anti-KEL alloantibodies and their considerable clinical significance. So far, only limited information was available on KEL variant alleles determining the rare silent KELnull and KELel phenotypes with absent or diminished KEL antigen expression detected only by adsorption-elution techniques, respectively.

Useful keywords (using NLM MeSH Indexing)

Alleles*

Amino Acid Sequence

Austria

Base Sequence

Blood Donors

DNA Mutational Analysis

Erythrocytes/immunology

Erythrocytes/metabolism

Flow Cytometry

Gene Frequency

Genetic Heterogeneity

Genetic Variation*

Genotype

Geography

Humans

Kell Blood-Group System/genetics*

Kell Blood-Group System/immunology

Molecular Sequence Data

Phenotype

Point Mutation

Polymerase Chain Reaction

Polymorphism, Genetic