Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

Background: Renal dysfunction (RD) may be associated with poor outcome in ischemic stroke patients treated with mechanical thrombectomy (MT), but data concerning this important and emerging comorbidity do not exist so far. Here, we investigated the influence of RD on postprocedural intracerebral hemorrhage (ICH), clinical outcome, and mortality in a large prospectively collected cohort of acute ischemic stroke patients treated with MT. Methods: Consecutive patients with anterior-circulation stroke treated with MT between October 2010 and January 2016 were included. RD was defined as glomerular filtration rate (GFR) < 60 mL/min/1.73 m(2). In a prospective database, clinical characteristics were recorded and brain images were analyzed for the presence of ICH after treatment in all patients. Clinical outcome was assessed by the modified Rankin Scale (mRS) after 3 months. To evaluate associations between clinical factors and outcomes uni- and multivariate regression analyses were conducted. Results: In total, 505 patients fulfilled all inclusion criteria (female: 49.7%, mean age: 71.0 years). RD at admission was present in 20.2%. RD patients were older and had cardiovascular risk factors more often. Multivariate regression analysis after adjustment for age, stroke severity, diabetes, hypertension, GFR, previous stroke, MT alone, or additional thrombolysis and recanalization results revealed that lower GFR was not independently associated with poor outcome (mRS 3-6; OR 1.13, 95% CI 0.99-1.28; p = 0.072) or ICH. However, lower GFR at admission was associated with a higher risk of mortality (OR 1.15, 95% CI 1.01-1.31; p = 0.038). Compared to admission, GFR values were higher at discharge (mean: 77.9 vs. 80.8 mL/min/1.73 m 2; p = 0.046). Conclusions: We did not find evidence for an association of lower GFR with an increased risk of poor outcome and ICH, but lower GFR was a determinant of 90-day mortality after endo-vascular stroke treatment. Our findings encourage also performing MT in this relevant subgroup of acute ischemic stroke patients. (C) 2017 S. Karger AG, Basel.

Useful keywords (using NLM MeSH Indexing)

Aged

Aged, 80 and over

Brain Ischemia/diagnosis

Brain Ischemia/mortality

Brain Ischemia/physiopathology

Brain Ischemia/surgery*

Cerebral Hemorrhage/etiology

Endovascular Procedures*/adverse effects

Endovascular Procedures*/methods

Endovascular Procedures*/mortality

Female

Glomerular Filtration Rate*

Humans

Kidney/physiopathology*

Kidney Diseases/diagnosis

Kidney Diseases/mortality

Kidney Diseases/physiopathology*

Male

Middle Aged

Prospective Studies

Recovery of Function

Risk Factors

Stroke/diagnosis

Stroke/mortality

Stroke/physiopathology

Stroke/surgery*

Thrombectomy*/adverse effects

Thrombectomy*/methods

Thrombectomy*/mortality

Time Factors

Treatment Outcome

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