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Forschungsdatenbank PMU-SQQUID

SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study.
COVIDSurg Collaborative, GlobalSurg Collaborative
Br J Surg. 2021; 108(9): 1056-1063.
Originalarbeiten (Zeitschrift)


Becker Johannes
Bittner Reinhard
Borhanian Kurosch
Dornauer Isabella
Emmanuel Klaus
Gabersek Ana
Gantschnigg Antonia
Grechenig Michael
Gruber Ricarda
Hutter Jörg
Jäger Tarkan
Koch Oliver Owen
Lechner Michael
Manzenreiter Lisa
Mayer Franz
Mühlbacher Iris
Presl Jaroslav
Russe Elisabeth
Schredl Philipp
Schwaiger Karl
Varga Martin
Weitzendorfer Michael
Wimmer Angela


Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling.
The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18-49, 50-69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty.
NNVs were more favourable in surgical patients than the general population. The most favourable NNVs were in patients aged 70 years or more needing cancer surgery (351; best case 196, worst case 816) or non-cancer surgery (733; best case 407, worst case 1664). Both exceeded the NNV in the general population (1840; best case 1196, worst case 3066). NNVs for surgical patients remained favourable at a range of SARS-CoV-2 incidence rates in sensitivity analysis modelling. Globally, prioritizing preoperative vaccination of patients needing elective surgery ahead of the general population could prevent an additional 58 687 (best case 115 007, worst case 20 177) COVID-19-related deaths in 1 year.
As global roll out of SARS-CoV-2 vaccination proceeds, patients needing elective surgery should be prioritized ahead of the general population.

Useful keywords (using NLM MeSH Indexing)







COVID-19 Vaccines/pharmacology*


Elective Surgical Procedures/methods*




Middle Aged

Postoperative Complications/prevention*


Preoperative Period

Prospective Studies



Young Adult