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Forschungsdatenbank PMU-SQQUID

Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.
Wang, T; Wagner, A; Gehwolf, R; Yan, W; Passini, FS; Thien, C; Weissenbacher, N; Lin, Z; Lehner, C; Teng, H; Wittner, C; Zheng, Q; Dai, J; Ni, M; Wang, A; Papadimitriou, J; Leys, T; Tuan, RS; Senck, S; Snedeker, JG; Tempfer, H; Jiang, Q; Zheng, MH; Traweger, A;
Sci Transl Med. 2021; 13(582):
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Gehwolf Renate
Lehner Christine
Tempfer Herbert
Traweger Andreas
Wagner Andrea

Abstract

Tendons and tendon interfaces have a very limited regenerative capacity, rendering their injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however, our knowledge on how loading affects tendon structure and functional adaption remains fragmentary. Here, we provide evidence that the matricellular protein secreted protein acidic and rich in cysteine (SPARC) is critically involved in the mechanobiology of tendons and is required for tissue maturation, homeostasis, and enthesis development. We show that tendon loading at the early postnatal stage leads to tissue hypotrophy and impaired maturation of Achilles tendon enthesis in