Forschungsdatenbank PMU-SQQUID

Pneumolysin-damaged cells benefit from non-homogeneous toxin binding to cholesterol-rich membrane domains.
Drücker, P; Bachler, S; Wolfmeier, H; Schoenauer, R; Köffel, R; Babiychuk, VS; Dittrich, PS; Draeger, A; Babiychuk, EB;
Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(8): 79-805.
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed PUBMED Central Full Text

PMU-Autor/inn/en

Wolfmeier Heidi

Abstract

Nucleated cells eliminate lesions induced by bacterial pore-forming toxins, such as pneumolysin via shedding patches of damaged plasmalemma into the extracellular milieu. Recently, we have shown that the majority of shed pneumolysin is present in the form of inactive pre-pores. This finding is surprising considering that shedding is triggered by Ca

Useful keywords (using NLM MeSH Indexing)

Bacterial Proteins/metabolism

Bacterial Shedding/immunology

Cell Line, Tumor

Cell Membrane/metabolism

Cell Membrane/microbiology

Cholesterol/metabolism

HEK293 Cells

Host-Pathogen Interactions/immunology*

Humans

Intravital Microscopy

Lipid Bilayers/immunology

Lipid Bilayers/metabolism*

Microfluidics

Pneumococcal Infections/immunology*

Pneumococcal Infections/microbiology

Streptococcus pneumoniae/physiology*

Streptolysins/metabolism