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Forschungsdatenbank PMU-SQQUID

Host-Derived Microvesicles Carrying Bacterial Pore-Forming Toxins Deliver Signals to Macrophages: A Novel Mechanism of Shaping Immune Responses.
Köffel, R; Wolfmeier, H; Larpin, Y; Besançon, H; Schoenauer, R; Babiychuk, VS; Drücker, P; Pabst, T; Mitchell, TJ; Babiychuk, EB; Draeger, A;
Front Immunol. 2018; 9: 1688
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Wolfmeier Heidi

Abstract

Bacterial infectious diseases are a leading cause of death. Pore-forming toxins (PFTs) are important virulence factors of Gram-positive pathogens, which disrupt the plasma membrane of host cells and can lead to cell death. Yet, host defense and cell membrane repair mechanisms have been identified: i.e., PFTs can be eliminated from membranes as microvesicles, thus limiting the extent of cell damage. Released into an inflammatory environment, these host-derived PFTs-carrying microvesicles encounter innate immune cells as first-line defenders. This study investigated the impact of microvesicle- or liposome-sequestered PFTs on human macrophage polarization


Useful keywords (using NLM MeSH Indexing)

Bacterial Toxins/immunology*

Cell-Derived Microparticles/immunology*

Cell-Derived Microparticles/metabolism*

Cytokines/metabolism

Host-Pathogen Interactions

Humans

Immunity

Immunomodulation

Immunophenotyping

Macrophages/immunology*

Macrophages/metabolism*

Models, Biological

Monocytes/immunology

Monocytes/metabolism

Phenotype

Pore Forming Cytotoxic Proteins/immunology*

Signal Transduction*


Find related publications in this database (Keywords)

macrophage polarization
microvesicles
liposomes
bacterial pore-forming toxins
host-defense