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Forschungsdatenbank PMU-SQQUID

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.
Warnecke, A; Harre, J; Staecker, H; Prenzler, N; Strunk, D; Couillard-Despres, S; Romanelli, P; Hollerweger, J; Lassacher, T; Auer, D; Pachler, K; Wietzorrek, G; Köhl, U; Lenarz, T; Schallmoser, K; Laner-Plamberger, S; Falk, CS; Rohde, E; Gimona, M;
Clin Transl Med. 2020; 10(8): e262
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Auer Daniela
Couillard-Després Sébastien
Gimona Mario
Hollerweger Julia Carolin
Laner-Plamberger Sandra
Lassacher Teresa
Pachler Karin
Rohde Eva
Romanelli Pasquale
Schallmoser Katharina
Strunk Dirk

Abstract

The lack of approved anti-inflammatory and neuroprotective therapies in otology has been acknowledged in the last decades and recent approaches are heralding a new era in the field. Extracellular vesicles (EVs) derived from human multipotent (mesenchymal) stromal cells (MSC) can be enriched in vesicular secretome fractions, which have been shown to exert effects (eg, neuroprotection and immunomodulation) of their parental cells. Hence, MSC-derived EVs may serve as novel drug candidates for several inner ear diseases. Here, we provide first evidence of a strong neuroprotective potential of human stromal cell-derived EVs on inner ear physiology. In vitro, MSC-EV preparations exerted immunomodulatory activity on T cells and microglial cells. Moreover, local application of MSC-EVs to the inner ear significantly attenuated hearing loss and protected auditory hair cells from noise-induced trauma in vivo. Thus, EVs derived from the vesicular secretome of human MSC may represent a next-generation biological drug that can exert protective therapeutic effects in a complex and nonregenerating organ like the inner ear.


Find related publications in this database (Keywords)

extracellular vesicles (EVs)
inner ear
neuroprotection
spiral ganglion neurons
umbilical cord***#8208
derived mesenchymal stromal cells (UC***#8208
MSC)