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Forschungsdatenbank PMU-SQQUID

Acute Exposure to Environmental Tobacco Smoke: A Controlled Study in Adults with Asthma.
Gaisberger, M; Wass, RE; Dobias, H; Grabcanovic-Musija, F; Weiss, G; Lamprecht, B; Kaiser, B; Studnicka, M; Hartl, A;
Respiration. 2020; 1-8
Originalarbeiten (Zeitschrift)


Dobias Heidemarie
Gaisberger Martin
Grabcanovic-Musija Fikreta
Hartl Arnulf Josef
Studnicka Michael
Weiss Gertraud


Short-term, indoor exposure to environmental tobacco smoke (ETS) is still highly prevalent; however, little is known about the acute lung response in adult asthma.
We investigated whether acute, experimental ETS exposure influences symptoms, lung function, and inflammatory parameters.
Human subjects with asthma (n = 23) were exposed for 180 min to either room air or ETS at 250, 450, or 850 µg/m3. Respiratory symptoms, lung function, and exhaled nitric oxide (FeNO) were measured. Additionally, blood samples were analyzed for pro- and anti-inflammatory cytokines.
Humans with asthma demonstrate an increase in respiratory symptoms at all levels of ETS exposure, while the forced expiratory volume in 1 s (FEV1) and FeNO decrease with increasing ETS. The anti-inflammatory cytokine interleukin (IL)-10 increases at intermediate ETS concentrations, whereas tumor necrosis factor (TNF)-α and IL-8 increase only at the highest ETS concentration.
Following 180 min of acute, experimental ETS exposure, we observed a significant increase in respiratory symptoms, a decrease in lung function, and an increase in inflammatory cytokines, indicating an acute lung response in asthma.

Find related publications in this database (Keywords)

Allergic asthma
Environmental tobacco smoke
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