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Forschungsdatenbank PMU-SQQUID

Acute Exposure to Environmental Tobacco Smoke: A Controlled Study in Adults with Asthma.
Gaisberger, M; Wass, RE; Dobias, H; Grabcanovic-Musija, F; Weiss, G; Lamprecht, B; Kaiser, B; Studnicka, M; Hartl, A;
Respiration. 2020; 1-8
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Dobias Heidemarie
Gaisberger Martin
Grabcanovic-Musija Fikreta
Hartl Arnulf Josef
Studnicka Michael
Weiss Gertraud

Abstract

BACKGROUND
Short-term, indoor exposure to environmental tobacco smoke (ETS) is still highly prevalent; however, little is known about the acute lung response in adult asthma.
We investigated whether acute, experimental ETS exposure influences symptoms, lung function, and inflammatory parameters.
Human subjects with asthma (n = 23) were exposed for 180 min to either room air or ETS at 250, 450, or 850 µg/m3. Respiratory symptoms, lung function, and exhaled nitric oxide (FeNO) were measured. Additionally, blood samples were analyzed for pro- and anti-inflammatory cytokines.
Humans with asthma demonstrate an increase in respiratory symptoms at all levels of ETS exposure, while the forced expiratory volume in 1 s (FEV1) and FeNO decrease with increasing ETS. The anti-inflammatory cytokine interleukin (IL)-10 increases at intermediate ETS concentrations, whereas tumor necrosis factor (TNF)-α and IL-8 increase only at the highest ETS concentration.
Following 180 min of acute, experimental ETS exposure, we observed a significant increase in respiratory symptoms, a decrease in lung function, and an increase in inflammatory cytokines, indicating an acute lung response in asthma.


Find related publications in this database (Keywords)

Allergic asthma
Environmental tobacco smoke
Lung function
Inflammation
Respiratory symptoms