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Forschungsdatenbank PMU-SQQUID

Understanding hyper-reflexia in acute motor axonal neuropathy (AMAN).
Versace, V; Campostrini, S; Rastelli, E; Sebastianelli, L; Nardone, R; Pucks-Faes, E; Saltuari, L; Kofler, M; Uncini, A
NEUROPHYSIOL CLIN. 2020; 50(3): 139-144.
Originalarbeiten (Zeitschrift)


Nardone Raffaele


Hyper-reflexia is occasionally seen in acute motor axonal neuropathy (AMAN), but its pathophysiology is unclear. We report a patient with AMAN following Campylobacter jejuni enteritis, who showed generalized hyper-reflexia, bilateral Hoffmann sign and right Babinski sign. MRI and transcranial magnetic stimulation of the motor cortex disclosed no corticospinal tract involvement. An extensive electrophysiological investigation documented α-motoneuron hyperexcitability and dysfunction of the interneuronal inhibitory circuits in the spinal anterior horn. We propose an immune-mediated damage of the spinal inhibitory interneuronal network as possible mechanism inducing hyper-reflexia in AMAN.

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