Forschungsdatenbank PMU-SQQUID

Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation.
Kaplan, MM; Sultana, N; Benedetti, A; Obermair, GJ; Linde, NF; Papadopoulos, S; Dayal, A; Grabner, M; Flucher, BE
Cell Rep. 2018; 23(13):3891-3904
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed Full Text

PMU-Autor/inn/en

Benedetti Ariane

Abstract

Formation of synapses between motor neurons and muscles is initiated by clustering of acetylcholine receptors (AChRs) in the center of muscle fibers prior to nerve arrival. This AChR patterning is considered to be critically dependent on calcium influx through L-type channels (Ca

Useful keywords (using NLM MeSH Indexing)

Animals

Calcium/metabolism*

Calcium Channels, L-Type/deficiency

Calcium Channels, L-Type/genetics

Calcium Channels, L-Type/metabolism

Calcium Signaling

Diaphragm/metabolism

Embryo, Mammalian/metabolism

Fetal Development

Mice

Mice, Knockout

Motor Neurons/physiology

Neuromuscular Junction/physiology*

Neuronal Outgrowth/physiology*

Receptor Protein-Tyrosine Kinases/metabolism

Receptors, Cholinergic/metabolism*

Ryanodine Receptor Calcium Release Channel/deficiency

Ryanodine Receptor Calcium Release Channel/genetics

Ryanodine Receptor Calcium Release Channel/metabolism

Sarcoplasmic Reticulum/metabolism