Forschungsdatenbank PMU-SQQUID

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.
Etemad, S; Obermair, GJ; Bindreither, D; Benedetti, A; Stanika, R; Di Biase, V; Burtscher, V; Koschak, A; Kofler, R; Geley, S; Wille, A; Lusser, A; Flockerzi, V; Flucher, BE
J Neurosci. 2014; 34(4):1446-1461
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed PUBMED Central Full Text

PMU-Autor/inn/en

Benedetti Ariane

Abstract

β4a > β4e). Together, these findings support isoform-specific functions of β4 splice variants in neurons, with β4b playing a dual role in channel modulation and gene regulation, whereas the newly detected β4e variant serves exclusively in calcium-channel-dependent functions.

Useful keywords (using NLM MeSH Indexing)

Amino Acid Sequence

Animals

Blotting, Western

Calcium Channels/genetics*

Calcium Channels/metabolism

Female

Gene Expression/genetics*

Hippocampus/metabolism

Immunohistochemistry

Male

Mice

Mice, Inbred BALB C

Mice, Knockout

Molecular Sequence Data

Neurons/metabolism*

Oligonucleotide Array Sequence Analysis

Patch-Clamp Techniques

Protein Isoforms/genetics

Protein Isoforms/metabolism

Protein Subunits/genetics

Protein Subunits/metabolism

Reverse Transcriptase Polymerase Chain Reaction

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