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Forschungsdatenbank PMU-SQQUID

Computed tomography angiography vs 3 T black-blood cardiovascular magnetic resonance for identification of symptomatic carotid plaques.
Grimm, JM; Schindler, A; Schwarz, F; Cyran, CC; Bayer-Karpinska, A; Freilinger, T; Yuan, C; Linn, J; Trelles, M; Reiser, MF; Nikolaou, K; Saam, T;
J Cardiovasc Magn Reson. 2014; 16:84
Originalarbeiten (Zeitschrift)


Grimm Jochen


The purpose of this prospective study was to perform a head-to-head comparison of the two methods most frequently used for evaluation of carotid plaque characteristics: Multi-detector Computed Tomography Angiography (MDCTA) and black-blood 3 T-cardiovascular magnetic resonance (bb-CMR) with respect to their ability to identify symptomatic carotid plaques.
22 stroke unit patients with unilateral symptomatic carotid disease and >50% stenosis by duplex ultrasound underwent MDCTA and bb-CMR (TOF, pre- and post-contrast fsT1w-, and fsT2w- sequences) within 15 days of symptom onset. Both symptomatic and contralateral asymptomatic sides were evaluated. By bb-CMR, plaque morphology, composition and prevalence of complicated AHA type VI lesions (AHA-LT6) were evaluated. By MDCTA, plaque type (non-calcified, mixed, calcified), plaque density in HU and presence of ulceration and/or thrombus were evaluated. Sensitivity (SE), specificity (SP), positive and negative predictive value (PPV, NPV) were calculated using a 2-by-2-table.
To distinguish between symptomatic and asymptomatic plaques AHA-LT6 was the best CMR variable and presence / absence of plaque ulceration was the best CT variable, resulting in a SE, SP, PPV and NPV of 80%, 80%, 80% and 80% for AHA-LT6 as assessed by bb-CMR and 40%, 95%, 89% and 61% for plaque ulceration as assessed by MDCTA. The combined SE, SP, PPV and NPV of bb-CMR and MDCTA was 85%, 75%, 77% and 83%, respectively.
Bb-CMR is superior to MDCTA at identifying symptomatic carotid plaques, while MDCTA offers high specificity at the cost of low sensitivity. Results were only slightly improved over bb-CMR alone when combining both techniques.

Useful keywords (using NLM MeSH Indexing)


Carotid Artery, Internal/diagnostic imaging*

Carotid Artery, Internal/pathology*

Carotid Stenosis/complications

Carotid Stenosis/diagnosis*

Carotid Stenosis/diagnostic imaging

Carotid Stenosis/pathology



Magnetic Resonance Imaging*


Middle Aged

Multidetector Computed Tomography*

Plaque, Atherosclerotic*

Predictive Value of Tests

Prospective Studies

Severity of Illness Index


Find related publications in this database (Keywords)

Plaque imaging
Ischemic stroke
Symptomatic carotid plaque
Cardiovascular magnetic resonance