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Forschungsdatenbank PMU-SQQUID

Macrophage CD163 expression in cerebrospinal fluid: association with subarachnoid hemorrhage outcome.
Thomas, AJ; Ogilvy, CS; Griessenauer, CJ; Hanafy, KA;
J Neurosurg. 2018; 131(1):47-53
Originalarbeiten (Zeitschrift)


Griessenauer Christoph


Even though heme-induced cerebral inflammation contributes to many of the adverse sequelae seen in patients with subarachnoid hemorrhage (SAH), little is known about the mechanism; mouse models have shown a critical role for macrophages/microglia. Macrophage CD163 is a hemoglobin scavenger receptor involved in blood clearance after SAH. The authors hypothesized that the modified Fisher score is independently associated with cerebrospinal fluid (CSF) macrophage CD163 expression on postictal day 1, and that CSF macrophage CD163 expression is associated with 1-month neurological outcome.

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