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Forschungsdatenbank PMU-SQQUID

Radiation dose escalation with modified fractionation schedules for locally advanced NSCLC: A systematic review.
Zehentmayr, F; Grambozov, B; Kaiser, J; Fastner, G; Sedlmayer, F;
Thorac Cancer. 2020; 11(6): 137-1385.
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PMU-Autor/inn/en

Fastner Gerd
Grambozov Brane
Kaiser Julia
Sedlmayer Felix
Zehentmayr Franz

Abstract

Concomitant chemo-radiotherapy (cCRT) with 60 Gy in 30 fractions is the standard of care for stage 111 non-small cell lung cancer (NSCLC). With a median overall survival of 28.7 months at best and maximum locoregional control rates of 70% at two years, the prognosis for these patients is still dismal. This systematic review summarizes data on dose escalation by alternative fractionation, which has been explored as a primary strategy to improve both local control and overall survival over the past three decades. A Pubmed literature search was performed according to the PRISMA guidelines. Because of the large variety of radiation regimens total doses were converted to EQD


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