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Forschungsdatenbank PMU-SQQUID

An empirical assessment of appearance descriptors applied to MRI for automated diagnosis of TLE and MCI.
Hofer, C; Kwitt, R; Holler, Y; Trinka, E; Uhl, A
COMPUT BIOL MED. 2020; 117: 103592
Originalarbeiten (Zeitschrift)


Höller Yvonne
Trinka Eugen


Objective: Differential diagnosis of mild cognitive impairment MCI and temporal lobe epilepsy TLE is a debated issue, specifically because these conditions may coincide in the elderly population. We evaluate automated differential diagnosis based on characteristics derived from structural brain MRI of different brain regions. Methods: In 22 healthy controls, 19 patients with MCI, and 17 patients with TLE we used scale invariant feature transform (SIFT), local binary patterns (LBP), and wavelet-based features and investigate their predictive performance for MCI and TLE. Results: The classification based on SIFT features resulted in an accuracy of 81% of MCI vs. TLE and reasonable generalizability. Local binary patterns yielded satisfactory diagnostic performance with up to 94.74% sensitivity and 88.24% specificity in the right Thalamus for the distinction of MCI vs. TLE, but with limited generalizable. Wavelet features yielded similar results as LPB with 94.74% sensitivity and 82.35% specificity but generalize better. Significance: Features beyond volume analysis are a valid approach when applied to specific regions of the brain. Most significant information could be extracted from the thalamus, frontal gyri, and temporal regions, among others. These results suggest that analysis of changes of the central nervous system should not be limited to the most typical regions of interest such as the hippocampus and parahippocampal areas. Region-independent approaches can add considerable information for diagnosis. We emphasize the need to characterize generalizability in future studies, as our results demonstrate that not doing so can lead to overestimation of classification results. Limitations: The data used within this study allows for separation of MCI and TLE subjects using a simple age threshold. While we present a strong indication that the presented method is age-invariant and therefore agnostic to this situation, new data would be needed for a rigorous empirical assessment of this findings.

Find related publications in this database (Keywords)

Mild cognitive impairment
Temporal lobe epilepsy
Local binary patterns
Scale-invariant feature transform
Magnetic resonance imaging