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Forschungsdatenbank PMU-SQQUID

Ferritin in glioblastoma.
Jaksch-Bogensperger, H; Spiegl-Kreinecker, S; Arosio, P; Eckl, P; Golaszewski, S; Ebner, Y; Al-Schameri, R; Strasser, P; Weis, S; Bresgen, N;
Br J Cancer. 2020; 122(10): 1441-1444.
Originalarbeiten (Zeitschrift)


Al-Schameri Abdul Rahman
Ebner Yvonne
Golaszewski Stefan
Jaksch-Bogensperger Heidi
Strasser Peter


Elevated levels of serum ferritin (SF) are observed in several types of cancer; however, little is known on the association between ferritin and glioma, the most frequent type of human primary brain tumour. Here we report that GBM patients show significantly increased pre-surgical SF levels (i.e. ferritinaemia) within the SF reference range and a marked ferritin immunoreactivity of resected tumour tissue. Our findings account for an indirect association between ferritin synthesis in glioma-tissue and altered SF levels, which limits the clinical value of SF as a tumour marker in glioma. Importantly, we show for the first time that GBM-derived glioma cells release ferritin in vitro, which exerts an apoptosis-stimulating activity. Albeit the pathophysiologic context of apoptosis induction by a tumour-derived ferritin remains to be defined, our findings account for a distinct growth-regulatory role of these ferritin species in tumour biology.