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Forschungsdatenbank PMU-SQQUID

Tissue ACE phenotyping in lung cancer.
Danilov, SM; Metzger, R; Klieser, E; Sotlar, K; Trakht, IN; Garcia, JGN;
PLoS One. 2019; 14(12): e0226553
Originalarbeiten (Zeitschrift)


Klieser Eckhard
Metzger Roman Patrick


Pulmonary vascular endothelium is the main metabolic site for Angiotensin I-Converting Enzyme (ACE)-mediated degradation of several biologically-active peptides (angiotensin I, bradykinin, hemo-regulatory peptide Ac-SDKP). Primary lung cancer growth and lung cancer metastases decrease lung vascularity reflected by dramatic decreases in both lung and serum ACE activity. We performed precise ACE phenotyping in tissues from subjects with lung cancer.