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Forschungsdatenbank PMU-SQQUID

Upregulation of mitotic bookmarking factors during enhanced proliferation of human stromal cells in human platelet lysate.
Laner-Plamberger, S; Oeller, M; Mrazek, C; Hartl, A; Sonderegger, A; Rohde, E; Strunk, D; Schallmoser, K;
J Transl Med. 2019; 17(1): 432
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Hartl Arnulf Josef
Laner-Plamberger Sandra
Mrazek Cornelia
Öller Michaela
Rohde Eva
Schallmoser Katharina
Sonderegger Alina
Strunk Dirk

Abstract

Innovative human stromal cell therapeutics require xeno-free culture conditions. Various formulations of human platelet lysate (HPL) are efficient alternatives for fetal bovine serum (FBS). However, a consistent lack of standardized manufacturing protocols and quality criteria hampers comparability of HPL-products. Aim of this study was to compare the biochemical composition of three differential HPL-preparations with FBS and to investigate their impact on stromal cell biology.


Find related publications in this database (Keywords)

Stromal cells
Pooled human platelet lysate (pHPL)
Fibrinogen
Fetal bovine serum (FBS)
Mitotic bookmarking
transcription factors