' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1.
Lehner, C; Spitzer, G; Gehwolf, R; Wagner, A; Weissenbacher, N; Deininger, C; Emmanuel, K; Wichlas, F; Tempfer, H; Traweger, A;
Dis Model Mech. 2019; 12(12):
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Deininger Christian
Emmanuel Katja
Gehwolf Renate
Lehner Christine
Spitzer Gabriel
Tempfer Herbert
Traweger Andreas
Wagner Andrea
Wichlas Florian

Abstract

Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined. Therefore, the aim of this study was to determine the presence of cells in healthy rodent and human tendon tissue fulfilling macrophage-like functions. Using various transgenic reporter mouse models, we demonstrate the presence of tendon-resident cells in the dense matrix of the tendon core expressing the fractalkine (Fkn) receptor CX3CR1 and its cognate ligand CX3CL1/Fkn. Pro-inflammatory stimulation of 3D tendon-like constructs


Useful keywords (using NLM MeSH Indexing)

Animals

CX3C Chemokine Receptor 1/metabolism*

Cell Movement

Chemokine CX3CL1/metabolism*

Epiregulin/metabolism

Female

Green Fluorescent Proteins/metabolism

Humans

Immune System

Inflammation

Macrophages/metabolism*

Male

Mice

Mice, Inbred C57BL

Mice, Transgenic

Rats

Rats, Inbred F344

Tendons/cytology*


Find related publications in this database (Keywords)

Fractalkine
CX3CL1
CX3CR1
Epiregulin
Macrophage-like
Inflammation
Tendon homeostasis
Tendinopathy