PMU-Autor/inn/en
Deininger ChristianAbstract
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined. Therefore, the aim of this study was to determine the presence of cells in healthy rodent and human tendon tissue fulfilling macrophage-like functions. Using various transgenic reporter mouse models, we demonstrate the presence of tendon-resident cells in the dense matrix of the tendon core expressing the fractalkine (Fkn) receptor CX3CR1 and its cognate ligand CX3CL1/Fkn. Pro-inflammatory stimulation of 3D tendon-like constructs
Useful keywords (using NLM MeSH Indexing)
Animals
CX3C Chemokine Receptor 1/metabolism*
Cell Movement
Chemokine CX3CL1/metabolism*
Epiregulin/metabolism
Female
Green Fluorescent Proteins/metabolism
Humans
Immune System
Inflammation
Macrophages/metabolism*
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Rats
Rats, Inbred F344
Tendons/cytology*
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Fractalkine