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Forschungsdatenbank PMU-SQQUID

Increased risk of stroke and myocardial infarction in patients with epilepsy: A systematic review of population-based cohort studies.
Brigo, F; Lochner, P; Nardone, R; Manganotti, P; Lattanzi, S;
Epilepsy Behav. 2020; 104(Pt B):106307
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PMU-Autor/inn/en

Nardone Raffaele

Abstract

OBJECTIVE
The objective of the study was to review the current epidemiological evidence about the relationship between epilepsy and increased risk of cardio- and cerebrovascular events.
We systematically searched MEDLINE (from inception to 19th October 2018) to identify population-based cohort studies evaluating the risk of subsequent stroke or myocardial infarction (MI) in patients with epilepsy without history of prior cerebrovascular disease in comparison with subjects without epilepsy.
A total of 16,641 records were screened, and 6 studies were included. Data on the risk of subsequent stroke and MI were provided by five and two studies, respectively. The adjusted hazard ratios (
Patients with epilepsy are at higher risk of subsequent stroke and MI in comparison with subjects without epilepsy. Although individual AEDs may carry different risks of cardio- and cerebrovascular disease, the clinical relevance of the metabolic effects of the enzyme-inducing AEDs is still uncertain. This article is part of the Special Issue "Seizures & Stroke".


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Epidemiology
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