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Forschungsdatenbank PMU-SQQUID

Therapeutic Plasma Exchange in Multiple Sclerosis and Autoimmune Encephalitis: a Comparative Study of Indication, Efficacy and Safety.
Moser, T; Harutyunyan, G; Karamyan, A; Otto, F; Bacher, C; Chroust, V; Leitinger, M; Novak, HF; Trinka, E; Sellner, J;
Brain Sci. 2019; 9(10):
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Leitinger Markus
Moser Tobias
Novak Helmut
Otto Ferdinand
Trinka Eugen

Abstract

Therapeutic plasma exchange (TPE) is a well-established method of treatment for steroid-refractory relapses in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Little is known about indications and clinical responses to TPE in autoimmune encephalitis and other immune-mediated disorders of the central nervous system (CNS). We performed a retrospective chart review of patients with immune-mediated disorders of the CNS undergoing TPE at our tertiary care center between 2003 and 2015. The response to TPE within a 3- to 6-month follow-up was scored with an established rating system. We identified 40 patients including 21 patients with multiple sclerosis (MS, 52.5%), 12 with autoimmune encephalitis (AE, 30%), and 7 with other immune-mediated CNS disorders (17.5%). Among patients with AE, eight patients had definite AE (Immunolobulin G for N-methyl-D-aspartate receptor


Find related publications in this database (Keywords)

multiple sclerosis
autoimmune encephalitis
plasma exchange
autoimmunity
immunotherapeutics
clinical outcomes