PMU-Autor/inn/en
Gueths Gomes FaustoAbstract
Cancer-associated thrombosis is one of the major causes of worse prognosis among tumor-bearing patients. Extracellular vesicles derived from cancer cells, which can be divided mainly into microvesicles and exosomes, can participate in several tumor progression phenomena. Tumor-derived microvesicles positive for tissue factor (TF) have been associated with thrombotic risk in certain cancer types. Cancer cell-derived exosomes, however, have not. In this study we evaluated the capacity of extracellular vesicles (EVs, containing both microvesicles and exosomes) derived from breast-cancer cell lines in promoting platelet activation, aggregation and plasma coagulation, in experiments that access both TF-dependent and -independent activities.
Useful keywords (using NLM MeSH Indexing)
Breast Neoplasms/genetics*
Breast Neoplasms/metabolism
Cell Line, Tumor
Extracellular Vesicles/metabolism*
Extracellular Vesicles/pathology
Female
Humans
Platelet Activation
Platelet Aggregation
Thromboplastin/metabolism*
Thrombosis/etiology*
Thrombosis/pathology
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Thrombosis