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Forschungsdatenbank PMU-SQQUID

Use of CT angiography in comparison with other imaging techniques for the determination of embolus and remnant size in experimental aneurysms embolized with hydrogel filaments.
Killer, M; McCoy, MR; Vestal, MC; Weitgasser, L; Cruise, GM;
AJNR Am J Neuroradiol. 2011; 32(5): 923-928.
Originalarbeiten (Zeitschrift)


Killer-Oberpfalzer Monika
McCoy Mark R.


BACKGROUND AND PURPOSE: Beam-hardening artifacts in CTA can be greatly reduced by using metal-free coils for aneurysm embolization. We compared the embolic masses and remnants of experimental rabbit aneurysms coiled with hydrogel filaments by using DSA, CIA and histology. MATERIALS AND METHODS: Embolization of 12 rabbit bifurcation aneurysms was performed with detachable hydrogel filaments. Six aneurysms were embolized as completely as possible, and 6 aneurysms were embolized incompletely to intentionally leave remnants. Three aneurysms in each group underwent follow-up at 4 and 13 weeks. DSA, MRA, and CTA were performed immediately before sacrifice. The harvested aneurysms were evaluated histologically. For each imaging technique, the areas of the embolic mass and remnant were determined by using image analysis. Results were compared by using paired t tests. RESULTS: CTAs were suitable for quantification of the embolus and remnant areas because only small streaking artifacts were evident. The areas of the embolus were larger on CTA compared with DSA and histologic sections. The areas of the remnant were larger on CIA and MRA compared with DSA and histologic sections. Like DSA and MRA, CIA was suitable for determining whether aneurysm retreatment was necessary, provided that loops of hydrogel filaments were not present in the parent artery. CONCLUSIONS: We demonstrated that C:TA is a technique with potential for surveillance of aneurysms treated with hydrogel filaments. Additional work is required to determine the accuracy of the technique compared with currently accepted imaging modalities of DSA and MRA.

Useful keywords (using NLM MeSH Indexing)


Cerebral Angiography/methods*

Embolization, Therapeutic/instrumentation*

Equipment Design

Equipment Failure Analysis



Intracranial Aneurysm/complications

Intracranial Aneurysm/radiography*

Intracranial Aneurysm/surgery*

Intracranial Embolism/etiology

Intracranial Embolism/prevention*


Intracranial Embolism/radiography*


Materials Testing


Reproducibility of Results

Sensitivity and Specificity


Treatment Outcome