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Forschungsdatenbank PMU-SQQUID

Risks and Benefits of Glioblastoma Resection in Older Adults: A Retrospective Austrian Multicenter Study.
Schwartz, C; Romagna, A; Stefanits, H; Zimmermann, G; Ladisich, B; Geiger, P; Rechberger, J; Winkler, S; Weiss, L; Fastner, G; Trinka, E; Weis, S; Spiegl-Kreinecker, S; Steinbacher, J; McCoy, M; Johannes, T; Gruber, A; Jahromi, BR; Niemelä, M; Winkler, PA; Thon, N;
World Neurosurg. 2020; 133:e583-e591
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Fastner Gerd
Ladisich Barbara
McCoy Mark R.
Romagna Alexander
Schwartz Christoph
Steinbacher Jürgen
Trinka Eugen
Weiss Lukas
Winkler Peter A.
Zimmermann Georg Johannes

Abstract

OBJECTIVE
To assess the prognostic profile, clinical outcome, treatment-associated morbidity, and treatment burden of elderly patients with glioblastoma (GBM) undergoing microsurgical tumor resection as part of contemporary treatment algorithms.
We retrospectively identified patients with GBM ≥65 years of age who were treated by resection at 2 neuro-oncology centers. Survival was assessed by Kaplan-Meier analyses; log-rank tests identified prognostic factors.
The study population included 160 patients (mean age, 73.1 ± 5.1 years), and the median contrast-enhancing tumor volume was 31.0 cm
Clinical outcome for elderly patients with GBM remains limited. Nonetheless, the observed treatment-associated morbidity and treatment burden were moderate in the patients, and patient age and performance status remained the strongest predictors for survival. The risks and benefits of tumor resection in the age of biomarker-adjusted treatment concepts require further prospective evaluation.


Find related publications in this database (Keywords)

Adjuvant treatment
Biomarker
Elderly
Glioblastoma multiforme
Outcome
Resection
Treatment-associated morbidity