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Forschungsdatenbank PMU-SQQUID

Dose-Dependent Cannabidiol-Induced Elevation of Intracellular Calcium and Apoptosis in Human Articular Chondrocytes.
Winklmayr, M; Gaisberger, M; Kittl, M; Fuchs, J; Ritter, M; Jakab, M;
J Orthop Res. 2019; 37(12):2540-2549
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Gaisberger Martin
Jakab Martin
Kittl Michael
Ritter Markus
Winklmayr Martina

Abstract

Cannabidiol (CBD) is the most abundant non-psychoactive compound of Cannabis sativa extracts. Cannabinoids have been shown to exhibit anti-inflammatory, analgesic, antioxidant, neuroprotective, and anti-tumorigenic effects. In the present study, we investigated the effects of CBD on human articular chondrocytes. Cell viability was determined by Resazurin assays. Apoptosis was analyzed by annexin-V/7-actinomycin D (7-AAD) staining followed by flow cytometry. Caspase 3/7 activity was measured with caspase assays. Intracellular Ca


Find related publications in this database (Keywords)

osteoarthritis
cannabidiol
CBD
chondrocyte
apoptosis
calcium
Ca2+
viability