Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimers disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem human brain tissues.
Useful keywords (using NLM MeSH Indexing)
Amyloid beta-Protein Precursor/genetics
Genetic Predisposition to Disease
Genome-Wide Association Study/methods*
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