Forschungsdatenbank PMU-SQQUID

DNA methylation analysis on purified neurons and glia dissects age and Alzheimers disease-specific changes in the human cortex.
Gasparoni, G; Bultmann, S; Lutsik, P; Kraus, TFJ; Sordon, S; Vlcek, J; Dietinger, V; Steinmaurer, M; Haider, M; Mulholland, CB; Arzberger, T; Roeber, S; Riemenschneider, M; Kretzschmar, HA; Giese, A; Leonhardt, H; Walter, J;
Epigenetics Chromatin. 2018; 11(1): 41
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed PUBMED Central Full Text

PMU-Autor/inn/en

Kraus Theo

Abstract

Epigenome-wide association studies (EWAS) based on human brain samples allow a deep and direct understanding of epigenetic dysregulation in Alzheimers disease (AD). However, strong variation of cell-type proportions across brain tissue samples represents a significant source of data noise. Here, we report the first EWAS based on sorted neuronal and non-neuronal (mostly glia) nuclei from postmortem human brain tissues.

Useful keywords (using NLM MeSH Indexing)

ADAM17 Protein/genetics

Aging/genetics*

Alzheimer Disease/genetics*

Amyloid beta-Protein Precursor/genetics

Autopsy

Cell Separation

DNA Methylation*

Epigenesis, Genetic

Epigenomics

Genetic Predisposition to Disease

Genome-Wide Association Study/methods*

Humans

Neuroglia/chemistry

Neuroglia/cytology*

Neurons/chemistry

Neurons/cytology*

Organ Specificity

Transcriptome

Find related publications in this database (Keywords)

DNA methylation
Epigenetics
Alzheimerxxxs disease
Neurodegeneration
Aging
Cell sorting
Neuron
Glia
Brain
EWAS