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Forschungsdatenbank PMU-SQQUID

Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug.
Gelosa, P; Bonfanti, E; Castiglioni, L; Delgado-Garcia, JM; Gruart, A; Fontana, L; Gotti, M; Tremoli, E; Lecca, D; Fumagalli, M; Cimino, M; Aigner, L; Abbracchio, MP; Sironi, L
Pharmacol Res. 2019; 142:223-236
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Aigner Ludwig

Abstract

Stroke is one of the main causes of death, neurological dysfunctions or disability in elderly. Neuroprotective drugs have been proposed to improve long-term recovery after stroke, but failed to reach clinical effectiveness. Hence, recent studies suggested that restorative therapies should combine neuroprotection and remyelination. Montelukast, an anti-asthmatic drug, was shown to exert neuroprotection in animal models of CNS injuries, but its ability to affect oligodendrocytes, restoring fiber connectivity, remains to be determined. In this study, we evaluated whether montelukast induces long-term repair by promoting fiber connectivity up to 8 weeks after middle cerebral artery occlusion (MCAo), using different experimental approaches such as in vivo diffusion magnetic resonance imaging (MRI), electrophysiological techniques, ex vivo diffusion tensor imaging (DTI)-based fiber tracking and immunohistochemistry. We found that, in parallel with a reduced evolution of ischemic lesion and atrophy, montelukast increased the DTI-derived axial diffusivity and number of myelin fibers, the density of myelin binding protein (MBP) and the number of GSTpi


Find related publications in this database (Keywords)

Stroke
Montelukast (MTK)
Oligodendrocyte precursor cells (OPCs)
MRI fiber tracking
Electrophysiological recording