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Forschungsdatenbank PMU-SQQUID

Stroke Accelerates and Uncouples Intrinsic and Synaptic Excitability Maturation of Mouse Hippocampal DCX
Ceanga, M; Keiner, S; Grünewald, B; Haselmann, H; Frahm, C; Couillard-Després, S; Witte, OW; Redecker, C; Geis, C; Kunze, A;
J Neurosci. 2019; 39(9):1755-1766
Originalarbeiten (Zeitschrift)


Couillard-Després Sébastien


Stroke robustly stimulates adult neurogenesis in the hippocampal dentate gyrus. It is currently unknown whether this process induces beneficial or maladaptive effects, but morphological and behavioral studies have reported aberrant neurogenesis and impaired hippocampal-dependent memory following stroke. However, the intrinsic function and network incorporation of adult-born granule cells (ABGCs) after ischemia is unclear. Using patch-clamp electrophysiology, we evaluated doublecortin-positive (DCX

Find related publications in this database (Keywords)

aberrant integration
adult neurogenesis
uncoupled maturation