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Forschungsdatenbank PMU-SQQUID

Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling.
Kittl, M; Dobias, H; Beyreis, M; Kiesslich, T; Mayr, C; Gaisberger, M; Ritter, M; Kerschbaum, HH; Jakab, M;
Cell Physiol Biochem. 2018; 50(4): 1460-1473.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Beyreis Marlena
Dobias Heidemarie
Gaisberger Martin
Jakab Martin
Kiesslich Tobias
Kittl Michael
Mayr Christian Reinhard
Ritter Markus

Abstract

The neutral, non-essential amino acid glycine has manifold functions and effects under physiological and pathophysiological conditions. Besides its function as a neurotransmitter in the central nervous system, glycine also exerts immunomodulatory effects and as an osmolyte it participates in cell volume regulation. During phagocytosis, glycine contributes to (local) cell volume-dependent processes like lamellipodium formation. Similar to the expansion of the lamellipodium we assume that glycine also affects the migration of microglial cells in a cell volume-dependent manner.


Find related publications in this database (Keywords)

Swelling-dependent chloride current
Cl-
ICIswell
VRAC
VSOR
Cell volume regulation
Glycine
Neutral amino acid transporter
Migration
Microglia