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Forschungsdatenbank PMU-SQQUID

When heat casts a spell on the DNA damage checkpoints.
Turner, T; Caspari, T;
Open Biol. 2014; 4:140008
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PMU-Autor/inn/en

Caspari Thomas

Abstract

Peregrine Laziosi (1265-1345), an Italian priest, became the patron saint of cancer patients when the tumour in his left leg miraculously disappeared after he developed a fever. Elevated body temperature can cause tumours to regress and sensitizes cancer cells to agents that break DNA. Why hyperthermia blocks the repair of broken chromosomes by changing the way that the DNA damage checkpoint kinases ataxia telangiectasia mutated (ATM) and ataxia telangiectasia and Rad3-related (ATR) are activated is an unanswered question. This review discusses the current knowledge of how heat affects the ATR-Chk1 and ATM-Chk2 kinase networks, and provides a possible explanation of why homeothermal organisms such as humans still possess this ancient heat response.


Useful keywords (using NLM MeSH Indexing)

Ataxia Telangiectasia Mutated Proteins/metabolism

Checkpoint Kinase 1

Checkpoint Kinase 2/metabolism

Chromosomes/metabolism

DNA Damage*

Histones/metabolism

Humans

Protein Kinases/metabolism

Reactive Oxygen Species/metabolism

Temperature


Find related publications in this database (Keywords)

hyperthermia
ATR
ATM
Chk1
Chk2
DNA damage checkpoint