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Forschungsdatenbank PMU-SQQUID

Retinal Pericytes: Characterization of Vascular Development-Dependent Induction Time Points in an Inducible NG2 Reporter Mouse Model.
Bruckner, D; Kaser-Eichberger, A; Bogner, B; Runge, C; Schrödl, F; Strohmaier, C; Silva, ME; Zaunmair, P; Couillard-Despres, S; Aigner, L; Rivera, FJ; Reitsamer, HA; Trost, A;
Curr Eye Res. 2018; 43(10): 1274-1285.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Aigner Ludwig
Bogner Barbara
Couillard-Després Sébastien
Kaser-Eichberger Alexandra
Mayr Daniela
Reitsamer Herbert
Rivera Gomez-Barris Francisco J.
Runge Christian
Schrödl Falk
Silva Maria Elena
Strohmaier Clemens
Zaunmair Pia
Zurl Andrea

Abstract

Purpose/aim of the study: In the retina, defects in pericytes (PCs) function/loss are associated with various complications; however, the exact pathological mechanisms are still not fully elucidated. Following the behavior of retina-resident PCs during health and disease will reveal new insights for both the understanding of pathological mechanisms and the development of new regenerative therapies for the treatment of retinopathies. The main goal of this study is to determine whether the NG2-reporter mouse (NG2CreER


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Pericyte
retina
inducible NG2-eGFP mouse model
vSMCs
fate mapping
NG2 promoter activity