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Forschungsdatenbank PMU-SQQUID

Decoupling of Local Metabolic Activity and Functional Connectivity Links to Amyloid in Alzheimer"s Disease.
Scherr, M; Pasquini, L; Benson, G; Nuttall, R; Gruber, M; Neitzel, J; Brandl, F; Sorg, C;
J Alzheimers Dis. 2018; 64(2): 405-415.
Originalarbeiten (Zeitschrift)


Scherr Martin


Both ongoing local metabolic activity (LMA) and corresponding functional connectivity (FC) with remote brain regions are progressively impaired in Alzheimer"s disease (AD), particularly in the posterior default mode network (pDMN); however, it is unknown how these impairments interact. It is well known that decreasing mean synaptic activity of a region, i.e., decreasing LMA, reduces the region"s sensitivity to afferent input from other regions, i.e., FC.

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