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Forschungsdatenbank PMU-SQQUID

Safety study: is there a pathologic IGF-1, PDGF and TGF-β cytokine expression caused by adjunct BMP-7 in tibial and femoral non-union therapy?
Fischer, C; Reiner, C; Schmidmaier, G; Doll, J; Child, C; Grutzner, PA; Biglari, B; Boxriker, S; Moghaddam, A
THER CLIN RISK MANAG. 2018; 14: 691-697.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en


Abstract

In this prospective safety study, we investigated if the characteristic cytokine expression during bone regeneration is manipulated by the local application of bone morphogenetic protein-7 (BMP-7) in non-union surgery. Therefore, the levels of insulin like growth factor 1 (IGF-1), platelet-derived growth factor AB (PDGF-AB) and transforming growth factor beta (TGF-β) were compared between patients with the gold standard use of autologous bone graft (ABG) and those with additional application of BMP-7 as part of the diamond concept.


Find related publications in this database (Keywords)

bone morphogenetic protein
cytokine
non-union
safety