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Forschungsdatenbank PMU-SQQUID

Bevacizumab Improves Achilles Tendon Repair in a Rat Model.
Tempfer, H; Kaser-Eichberger, A; Lehner, C; Gehwolf, R; Korntner, S; Kunkel, N; Wagner, A; Gruetz, M; Heindl, LM; Schroedl, F; Traweger, A;
Cell Physiol Biochem. 2018; 46(3):114-1158
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Gehwolf Renate
Kaser-Eichberger Alexandra
Korntner Stefanie
Kunkel Nadja
Lehner Christine
Schrödl Falk
Tempfer Herbert
Traweger Andreas
Wagner Andrea

Abstract

Effective wound-healing generally requires efficient re-vascularization after injury, ensuring sufficient supply with oxygen, nutrients, and various cell populations. While this applies to most tissues, tendons are mostly avascular in nature and harbor relatively few cells, probably contributing to their poor regenerative capacity. Considering the minimal vascularization of healthy tendons, we hypothesize that controlling angiogenesis in early tendon healing is beneficial for repair tissue quality and function.


Useful keywords (using NLM MeSH Indexing)

Achilles Tendon/pathology

Animals

Bevacizumab/pharmacology

Bevacizumab/therapeutic use*

Disease Models, Animal

Elastic Modulus

Female

Gait/physiology

Neovascularization, Physiologic/drug effects

Rats

Rats, Inbred Lew

Tendon Injuries/drug therapy*

Tendon Injuries/pathology

Tensile Strength

Wound Healing/drug effects


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Antiangiogenic treatment
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Rat tendon defect model
VEGF-A