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Forschungsdatenbank PMU-SQQUID

Bevacizumab Improves Achilles Tendon Repair in a Rat Model.
Tempfer, H; Kaser-Eichberger, A; Lehner, C; Gehwolf, R; Korntner, S; Kunkel, N; Wagner, A; Gruetz, M; Heindl, LM; Schroedl, F; Traweger, A;
Cell Physiol Biochem. 2018; 46(3):1148-1158
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Kaser-Eichberger Alexandra
Schrödl Falk
Tempfer Herbert

Abstract

Effective wound-healing generally requires efficient re-vascularization after injury, ensuring sufficient supply with oxygen, nutrients, and various cell populations. While this applies to most tissues, tendons are mostly avascular in nature and harbor relatively few cells, probably contributing to their poor regenerative capacity. Considering the minimal vascularization of healthy tendons, we hypothesize that controlling angiogenesis in early tendon healing is beneficial for repair tissue quality and function.


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