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Forschungsdatenbank PMU-SQQUID

Factors affecting Volume changes of the somatosensory cortex in Patients with spinal cord injury: To Be considered for Future neuroprosthetic Design
Holler, Y; Tadzic, A; Thomschewski, AC; Holler, P; Leis, S; Tomasi, SO; Hofer, C; Bathke, A; Nardone, R; Trinka, E
FRONT NEUROL. 2017; 8: 662
Originalarbeiten (Zeitschrift)


Höller Peter
Höller Yvonne
Leis Stefan
Nardone Raffaele
Thomschewski Aljoscha
Tomasi Santino Ottavio
Trinka Eugen


Spinal cord injury (SCI) leads to severe chronic disability, but also to secondary adaptive changes upstream to the injury in the brain which are most likely induced due to the lack of afferent information. These neuroplastic changes are a potential target for innovative therapies such as neuroprostheses, e.g., by stimulation in order to evoke sensation or in order to suppress phantom limb pain. Diverging results on gray matter atrophy have been reported in patients with SCI. Detectability of atrophy seems to depend on the selection of the regions of interest, while whole-brain approaches are not sensitive enough. In this study, we discussed previous research approaches and analyzed differential atrophic changes in incomplete SCI using manual segmentation of the somatosensory cortex. Patients with incomplete SCI (ASIA C-D), with cervical (N = 5) and thoracic (N = 6) injury were included. Time since injury was ≤12 months in 7 patients, and 144, 152, 216, and 312 months in the other patients. Age at the injury was ≤26 years in 4 patients and ≥50 years in 7 patients. A sample of 12 healthy controls was included in the study. In contrast to all previous studies that used voxel-based morphometry, we performed manual segmentation of the somatosensory cortex in the postcentral gyrus from structural magnetic resonance images and normalized the calculated volumes against the sum of volumes of an automated whole-head segmentation. Volumes were smaller in patients than in controls (

Find related publications in this database (Keywords)

spinal cord injury
somatosensory cortex