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Forschungsdatenbank PMU-SQQUID

Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection.
Brechmann, T; Swol, J; Knop-Hammad, V; Willert, J; Aach, M; Cruciger, O; Schmiegel, W; Schildhauer, TA; Hamsen, U;
World J Gastroenterol. 2015; 21(12):3736-3740
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Swol Justyna

Abstract

A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile (C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.


Useful keywords (using NLM MeSH Indexing)

Aged

Clostridium difficile/isolation*

purification*

Colonoscopy

Enterocolitis, Pseudomembranous/diagnosis

Enterocolitis, Pseudomembranous/microbiology

Enterocolitis, Pseudomembranous/therapy*

Fecal Microbiota Transplantation*/methods

Feces/microbiology

Humans

Intestines/microbiology*

Male

Microbiota*

Quadriplegia/etiology*

Severity of Illness Index

Spinal Cord Injuries/complications*

Treatment Outcome


Find related publications in this database (Keywords)

Clostridium difficile infection
Spinal cord injury
Fecal microbiota transplantation
Systemic inflammatory response syndrome