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Forschungsdatenbank PMU-SQQUID

Functional therapies for cutaneous wound repair in epidermolysis bullosa.
Peking, P; Koller, U; Murauer, EM;
Adv Drug Deliv Rev. 2018; 129:330-343
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Ebner Patricia
Koller Ulrich
Murauer Eva Maria

Abstract

Chronic wounding as a result of recurrent skin blistering in the painful genetic skin disease epidermolysis bullosa, may lead to life-threatening infections, increased risk of tumor formation, and other serious medical complications. Therefore, epidermolysis bullosa patients have an urgent need for optimal wound care and tissue regeneration. Therapeutic strategies using gene-, protein-, and cell-therapies are being developed to improve clinical symptoms, and some of them have already been investigated in early clinical trials. The most favorable options of functional therapies include gene replacement, gene editing, RNA targeting, and harnessing natural gene therapy. This review describes the current progress of the different approaches targeting autologous skin cells, and will discuss the benefits and challenges of their application.


Find related publications in this database (Keywords)

Genodermatoses
Wound healing
Autologous skin cells
Stem cells
In vivo therapy
Ex vivo therapy