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Forschungsdatenbank PMU-SQQUID

Oligometastases in Genitourinary Tumors: Recent Insights and Future Molecular Diagnostic Approach
Conti, A; D'Elia, C; Cheng, M; Santoni, M; Piva, F; Brunelli, M; Lopez-Beltran, A; Giulietti, M; Scarpelli, M; Pycha, A; Galosi, AB; Artibani, W; Cheng, L; Montironi, R; Battelli, N; Lusuardi, L
EUR UROL SUPPL. 2017; 16(12): 309-315.
Originalarbeiten (Zeitschrift)


Lusuardi Lukas


Context: An oligometastatic state is an early event during tumor metastatic spread and is rarely reported in patients with genitourinary tumors. In this condition, the primary tumor has low capacity for distal dissemination because its aggressiveness has not yet reached a maximum. Objective: To review recent findings on the diagnosis and treatment of oligometastatic disease in patients with genitourinary tumors. Evidence acquisition: To identify relevant studies, we reviewed articles in PubMed from January 1966 to September 2017. The search was conducted by combining the words "oligometastasisxxxxxx or "oligometastatic diseasexxxxxx with "bladder cancerxxxxxx, "genitourinary tumorxxxxxx, "prostate cancerxxxxxx, and "renal cancerxxxxxx. Evidence synthesis: In renal cell carcinoma (RCC), tumors from patients with multiple metastases showed a different gene signature compared to oligometastatic RCC. In addition, an oligometastatic state was an independent prognostic factor for overall survival (OS). Otherwise, the characteristics of oligometastases from bladder cancer remain unclear, as do the clinical and prognostic significance of metastasectomy in this setting. However, patients with oligometastatic prostate cancer have longer recurrence-free survival and OS and seem to benefit from local metastasis-directed therapies. Conclusions: Early detection of oligometastatic disease in patients with genitourinary tumors is fundamental in improving outcomes by identifying patients who would benefit from local approaches with potentially curative rather than palliative intent. (C) 2017 Published by Elsevier B.V. on behalf of European Association of Urology.

Find related publications in this database (Keywords)

Bladder cancer
Early diagnosis
Genitourinary tumors
Prostate cancer
Kidney cancer