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Forschungsdatenbank PMU-SQQUID

Exploring the molecular basis of insecticide resistance in the dengue vector Aedes aegypti: a case study in Martinique Island (French West Indies).
Marcombe, S; Poupardin, R; Darriet, F; Reynaud, S; Bonnet, J; Strode, C; Brengues, C; Yébakima, A; Ranson, H; Corbel, V; David, JP;
BMC Genomics. 2009; 10:494
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Poupardin Rodolphe

Abstract

The yellow fever mosquito Aedes aegypti is a major vector of dengue and hemorrhagic fevers, causing up to 100 million dengue infections every year. As there is still no medicine and efficient vaccine available, vector control largely based on insecticide treatments remains the only method to reduce dengue virus transmission. Unfortunately, vector control programs are facing operational challenges with mosquitoes becoming resistant to commonly used insecticides. Resistance of Ae. aegypti to chemical insecticides has been reported worldwide and the underlying molecular mechanisms, including the identification of enzymes involved in insecticide detoxification are not completely understood.


Useful keywords (using NLM MeSH Indexing)

Aedes/drug effects

Aedes/enzymology

Aedes/genetics*

Animals

DNA Mutational Analysis

Genes, Insect

Inactivation, Metabolic/genetics

Insect Vectors/drug effects

Insect Vectors/enzymology

Insect Vectors/genetics*

Insecticide Resistance/genetics*

Insecticides/pharmacokinetics

Insecticides/pharmacology*

Larva/drug effects

Larva/enzymology

Larva/genetics

Martinique

Mosquito Control/methods

Oligonucleotide Array Sequence Analysis