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Forschungsdatenbank PMU-SQQUID

Transcriptome response to pollutants and insecticides in the dengue vector Aedes aegypti using next-generation sequencing technology.
David, JP; Coissac, E; Melodelima, C; Poupardin, R; Riaz, MA; Chandor-Proust, A; Reynaud, S;
BMC Genomics. 2010; 11:216
Originalarbeiten (Zeitschrift)


Poupardin Rodolphe


The control of mosquitoes transmitting infectious diseases relies mainly on the use of chemical insecticides. However, mosquito control programs are now threatened by the emergence of insecticide resistance. Hitherto, most research efforts have been focused on elucidating the molecular basis of inherited resistance. Less attention has been paid to the short-term response of mosquitoes to insecticides and pollutants which could have a significant impact on insecticide efficacy. Here, a combination of LongSAGE and Solexa sequencing was used to perform a deep transcriptome analysis of larvae of the dengue vector Aedes aegypti exposed for 48 h to sub-lethal doses of three chemical insecticides and three anthropogenic pollutants.

Useful keywords (using NLM MeSH Indexing)

Aedes/drug effects*


Environmental Pollutants/pharmacology*

Gene Expression Profiling*

Insect Proteins/analysis*