In the city of Yaoundé in Cameroon malaria is predominately transmitted by the M and S molecular forms of Anopheles gambiae and both are resistant to the pyrethroid insecticides and DDT. Mutations in the target site of these insecticides, present at a high frequency in malaria vectors in this city, contribute to this resistance profile. To identify additional resistance mechanisms, the expression profile of multiple DDT-resistant field populations of M and S molecular forms was compared to laboratory-susceptible populations.
Useful keywords (using NLM MeSH Indexing)
ATP-Binding Cassette Transporters/genetics
Cytochrome P-450 Enzyme System/genetics
Gene Expression Profiling
Gene Expression Regulation*
Insecticide Resistance/drug effects
Oligonucleotide Array Sequence Analysis