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Forschungsdatenbank PMU-SQQUID

Resistance to DDT in an urban setting: common mechanisms implicated in both M and S forms of Anopheles gambiae in the city of Yaoundé Cameroon.
Fossog Tene, B; Poupardin, R; Costantini, C; Awono-Ambene, P; Wondji, CS; Ranson, H; Antonio-Nkondjio, C;
PLoS One. 2013; 8(4):e61408
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Poupardin Rodolphe

Abstract

In the city of Yaoundé in Cameroon malaria is predominately transmitted by the M and S molecular forms of Anopheles gambiae and both are resistant to the pyrethroid insecticides and DDT. Mutations in the target site of these insecticides, present at a high frequency in malaria vectors in this city, contribute to this resistance profile. To identify additional resistance mechanisms, the expression profile of multiple DDT-resistant field populations of M and S molecular forms was compared to laboratory-susceptible populations.


Useful keywords (using NLM MeSH Indexing)

ATP-Binding Cassette Transporters/genetics

Animals

Anopheles/classification

Anopheles/genetics*

Cameroon

Cytochrome P-450 Enzyme System/genetics

DDT/metabolism

DDT/pharmacology

Gene Expression Profiling

Gene Expression Regulation*

Gene Frequency

Genotype

Glucuronosyltransferase/genetics

Glutathione Transferase/genetics

Inactivation, Metabolic/genetics*

Insect Proteins/genetics*

Insecticide Resistance/drug effects

Insecticide Resistance/genetics*

Insecticides/metabolism

Insecticides/pharmacology*

Oligonucleotide Array Sequence Analysis

Pyrethrins/metabolism

Pyrethrins/pharmacology

Urban Health