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Forschungsdatenbank PMU-SQQUID

Identification of carboxylesterase genes implicated in temephos resistance in the dengue vector Aedes aegypti.
Poupardin, R; Srisukontarat, W; Yunta, C; Ranson, H;
PLoS Negl Trop Dis. 2014; 8(3):e2743
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Poupardin Rodolphe

Abstract

Thailand is currently experiencing one of its worst dengue outbreaks in decades. As in most countries where this disease is endemic, dengue control in Thailand is largely reliant on the use of insecticides targeting both immature and adult stages of the Aedes mosquito, with the organophosphate insecticide, temephos, being the insecticide of choice for attacking the mosquito larvae. Resistance to temephos was first detected in Aedes aegypti larvae in Thailand approximately 25 years ago but the mechanism responsible for this resistance has not been determined.


Useful keywords (using NLM MeSH Indexing)

Aedes/drug effects*

Aedes/enzymology*

Aedes/genetics

Animals

Biological Assay

Carboxylesterase/genetics*

Carboxylesterase/metabolism*

Dengue/epidemiology

Dengue/transmission

Gene Duplication

Gene Expression Profiling

Insect Vectors

Insecticide Resistance*

Insecticides/pharmacology*

Microarray Analysis

Polymorphism, Genetic

Sequence Analysis, DNA

Temefos/pharmacology*

Thailand/epidemiology

Up-Regulation