' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

The microanatomy of spinal cord injury: a review.
Mortazavi, MM; Verma, K; Harmon, OA; Griessenauer, CJ; Adeeb, N; Theodore, N; Tubbs, RS;
Clin Anat. 2015; 28(1): 27-36.
├ťbersichtsarbeiten

PMU-Autor/inn/en

Griessenauer Christoph

Abstract

Spinal cord injury is a highly prevalent condition associated with significant morbidity and mortality. The pathophysiology underlying it is extraordinarily complex and still not completely understood. We performed a comprehensive literature review of the pathophysiologic processes underlying spinal cord injury. The mechanisms underlying primary and secondary spinal cord injury are distinguished based on a number of factors and include the initial mechanical injury force, the vascular supply of the spinal cord which is associated with spinal cord perfusion, spinal cord autoregulation, and post-traumatic ischemia, and a complex inflammatory cascade involving local and infiltrating immunomodulating cells. This review illustrates the current literature regarding the pathophysiology behind spinal cord injury and outlines potential therapeutic options for reversing these mechanisms.


Useful keywords (using NLM MeSH Indexing)

Cerebrospinal Fluid Pressure

Evoked Potentials

Homeostasis

Humans

Inflammation/immunology

Inflammation/metabolism*

Ischemia/physiopathology*

Spinal Cord/blood supply*

Spinal Cord Compression/physiopathology*

Spinal Cord Injuries/pathology*

Spinal Cord Injuries/physiopathology*

Spinal Cord Injuries/therapy


Find related publications in this database (Keywords)

spinal cord
injury
mechanisms
vascular
compromise
therapy
inflammation