PMU-Autor/inn/en
Ablinger MichaelAbstract
Due to its unique immunological properties, the skin is an attractive target tissue for allergen-specific immunotherapy. In our current work, we combined a dendritic cell targeting approach with epicutaneous immunization using an ablative fractional laser to generate defined micropores in the upper layers of the skin. By coupling the major birch pollen allergen Bet v 1 to mannan from S. cerevisiae via mild periodate oxidation we generated hypoallergenic Bet-mannan neoglycoconjugates, which efficiently targeted CD14
Useful keywords (using NLM MeSH Indexing)
Administration, Cutaneous
Allergens/administration*
dosage*
Animals
Antigens, Plant/administration*
dosage*
Complement Activation
Dendritic Cells/immunology*
Female
Humans
Immunoglobulin E/immunology
Lasers*
Mannans/administration*
dosage*
Mice, Inbred BALB C
Porosity
Skin/immunology*
Th1 Cells/immunology
Th17 Cells/immunology
Vaccination/methods*
Find related publications in this database (Keywords)
Dendritic cell targeting