Forschungsdatenbank PMU-SQQUID

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination.
De La Fuente, AG; Lange, S; Silva, ME; Gonzalez, GA; Tempfer, H; van Wijngaarden, P; Zhao, C; Di Canio, L; Trost, A; Bieler, L; Zaunmair, P; Rotheneichner, P; OSullivan, A; Couillard-Despres, S; Errea, O; Mäe, MA; Andrae, J; He, L; Keller, A; Bátiz, LF; Betsholtz, C; Aigner, L; Franklin, RJM; Rivera, FJ;
Cell Rep. 2017; 20(8):1755-1764
Originalarbeiten (Zeitschrift)

Abstract/Keywords Web of Science PubMed PUBMED Central Full Text

PMU-Autor/inn/en

Aigner Ludwig
Bieler Lara Sophie
Couillard-Després Sébastien
Lange Simona
O'Sullivan Anna
Rivera Gomez-Barris Francisco J.
Rotheneichner Peter
Tempfer Herbert
Zaunmair Pia
Zurl Andrea

Abstract

The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfb

Useful keywords (using NLM MeSH Indexing)

Animals

Cell Differentiation/physiology

Cells, Cultured

Central Nervous System/cytology

Central Nervous System/metabolism

Central Nervous System/physiology*

Demyelinating Diseases

Humans

Mice

Nerve Regeneration/physiology

Oligodendroglia/cytology

Oligodendroglia/metabolism

Oligodendroglia/physiology*

Pericytes/cytology

Pericytes/metabolism

Pericytes/physiology*