Prevention and early recognition of critical illness in patients with autoimmune encephalitis (AE) is essential to achieve better outcome.
To evaluate risk factors for intensive care unit (ICU) admission and its prognostic impact in patients with AE.
A reclassification of patients hospitalized between 2011 and 2016 revealed 17 "definite" and 15 "probable" AE cases. Thirteen patients (41%) developed critical illness and required ICU admission. The underlying conditions were intractable seizures or status epilepticus (54%), altered mental state (39%), and respiratory failure (8%).
ICU admission was associated with longer time from first symptoms to hospitalization (
We confirmed the need for ICU care in a subgroup of patients and the prevailing objective is improved seizure control, and definite diagnosis of AE and anemia were identified as risk factors for development of critical illness. However, prognosis was not affected by ICU admission.
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