Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

Alloimmunization to Red Blood Cell (RBC) antigens frequently occurs in patients with myeloid neoplasms (AML, MDS and CMML) and potentially poses the patient at risk for delayed hemolytic transfusion reactions and limited supply of compatible RBC-units. However, there is comparatively little data on transfusion associated characteristics in this patient cohort. We therefore retrospectively analyzed transfusion requirements and clinical outcomes of 184 patients with myloid neoplasms treated with azacitidine at the Paracelsus Medical University Salzburg, which were included in the Austrian Registry of Hypomethylating Agents. The mean blood component requirements for AML, MDS and CMML were 39.8, 67.4 and 31.4 RBC units and 31.7, 27.6 and 19.1 platelet (PLT) units respectively. In spite of an extended and stringent RBC unit matching policy (ABO, RhD, RhCcEe and K antigens), 20 (11%) patients formed at least one alloantibody ("allo-group"), whereas 164 patients (89%) did not ("non-allo-group"). The most frequent antibody specificity was anti-E, followed by anti-Wra -Lua, -D, -C and -Jka. Alloimmunization was associated with higher numbers of transfused RBC units (68 vs. 38; p=0.001), as well as with longer time under transfusion (16.7 vs. 9.4 months; p=0.014). Median overall survival (OS) did not differ significantly between the "allo"- and "non-allo-group".

Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Antimetabolites, Antineoplastic/therapeutic use

Azacitidine/therapeutic use

Erythrocyte Transfusion/adverse effects

Erythrocyte Transfusion/methods

Erythrocytes/immunology*

Female

Humans

Isoantibodies/blood

Leukemia, Myelogenous, Chronic, BCR-ABL Positive/complications

Leukemia, Myelogenous, Chronic, BCR-ABL Positive/mortality

Leukemia, Myelogenous, Chronic, BCR-ABL Positive/therapy

Leukemia, Myeloid, Acute/complications

Leukemia, Myeloid, Acute/mortality

Leukemia, Myeloid, Acute/therapy

Male

Middle Aged

Myelodysplastic Syndromes/complications

Myelodysplastic Syndromes/mortality

Myelodysplastic Syndromes/therapy*

Retrospective Studies

Survival Rate

Transfusion Reaction/etiology

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