PMU-Autor/inn/en
Heussinger NicoleAbstract
We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR] = 5.94, 95% confidence interval [CI] = 3.39-10.39, p < 0.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR = 3.69, 95% CI = 2.32-5.86, p < 0.001), and age (HR = 1.08 per year of age, 95% CI = 1.02-1.13, p = 0.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI = 12.26-58.74, p < 0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON.
Useful keywords (using NLM MeSH Indexing)
Adolescent
Age Factors
Child
Child, Preschool
Disease Progression*
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Multiple Sclerosis/cerebrospinal fluid*
Multiple Sclerosis/pathology*
Oligoclonal Bands/cerebrospinal fluid*
Optic Neuritis/cerebrospinal fluid*
Optic Neuritis/pathology*
Prognosis
Proportional Hazards Models
Retrospective Studies